This issue of Medical Clinics, guest edited by Dr. Brian Garibaldi, is devoted to Clinical Examination. Articles in this issue include: Introduction to the Clinical Examination; The Enduring Diagnostic Value of the Physical Exam; The Physical Exam as Ritual – Social Sciences in the Context of the Physical Exam; The Hypothesis Driven Physical Exam; The Role of Technology in the “Clinical Exam 2.0”; Clinical Reasoning at the Bedside; The Outpatient Clinical Exam; The Electronic Health Record and the Clinical Exam; Communication and Ethics in the Clinical Exam; Improving Observational Skills to Enhance the Clinical Exam; The Role of Bedside Rounds in the Clinical Examination; Communication with Patients from Culturally and Socially Diverse Populations; Telemedicine and the Clinical Exam; Clinical Skills Assessment in the 21st Century; and Emerging Tools to Enhance Clinical Reasoning Skills.